Совет по здравоохранению Нидерландов критикует МАИР

Work published: scientific papers and materials of the Fifth International Symposium 26-May 28, 2008 Vol. 3. Kazan. 2008.
THE EFFECT OF EXCESS CHLORIDES ON THE EMERGENCE OF STATE-ÈZOFAGITOV HYPERACID, GASTRITIS, DUODENITIS, ENTERITIS, ULCERATIVE COLITIS, ULCERS OF THE ESOPHAGUS, STOMACH AND DUODENAL ULCERS, ESOPHAGEAL CANCER, STOMACH CANCER AND BOWEL CANCER (NEW BIOGEOHIMIČESKAÂ ODNOPRIČINNAÂ PARADIGM)
B.v. Larionov
The Committee for the study of the phenomena of nature and human ecology RT (Kazan)
“Enigma of the ulcer still not solved”-Professor S. Rapoport [1].
When I wrote a monograph on salt and hypertension-Bv Larionov [2], read the work of Ephraim, Z.k., R.i. Krylova “features of experimental hypertension and the pathological feature changes in monkeys with chronic stress table salt” [3]. After that, I began to search for publications by the excess consumption of salt with a group of diseases, which I called giperacidizmom. Then I wrote a book called “how to save teeth?”, released as a self-published-Bv Larionov [4], but continued to collect materials on giperacidozam. Z.k. Efremova, R.i. Krylova [3], studied the effect of the salt diet on the development of hypertension in monkeys, but the first in the world to describe and change them in the gastrointestinal tract. In the experiment used 31 monkey species of hamadryas Baboon Baboon, ranging in age from 2 months to 7 years old (by the beginning of the experiment), including 4 calves from their mothers on the salt diet. The monkeys received NaCl in the amount of 2-3% of the total weight of food (26-30 g for adults and 8-16, 2011 for teens) every day. In the course of the experiment killed 13 monkeys, found defects in the stomach mucous membrane type erosions or ulcers in the intestine is a constant phenomenon of inflammation: from small hemorrhages in the Mucosa to paintings express katarral′nogo inflammation in a particular department. When bacteriological examination of pathogenic flora is not to …The immediate cause of death for 7 monkeys, have been the phenomenon of inflammation in the mucosa of the stomach, liver, heart and adrenal gland. I.s. Glazunov [5] refers to a very interesting data: as for stomach cancer, the hypothesis is that excessive salt intake increases the acidity of gastric juice and gastric lesions rise accordingly-(102-104). ” Rannak E.d. [6] wrote: there is an indication that the salted or bezsol′naâ diet has beneficial effects not only the swelling, inflammation of the kidneys and high blood pressure, but when the chest the Toad (strokes), arteriosclerosis, gastric ulcers and duodeny (duodenum-duodenum), glaucoma, etc. Šeptulin A. A., Kurteanu B. N. [7] presented the modern theory of pathogenesis of peptic ulcer disease: acid-peptic aggression back diffusion of hydrogen ions, duodenogastral′nogo reflux, gastritičeskih changes vascular disorders. This article was for us further proof that only one is our theory is a paradigm of the acid aggression due to excess HCl education, due to excess intake of NaCl. V.k. Fadeeva [8] in experiments on rats has received reports that in the blood of rats “is increasing the number of Na and Cl, since concentrations of Cl (in water) 1 g/l and above. S. Radbil′, s. Weinstein [9, p. 91] have studied the contents of Na in mixed saliva at 195 patients with various diseases of the stomach and duodeny of 89 patients with peptic ulcer. It turned out that the concentration of Na in giperacidnom gastritis and ulcers was significantly higher than normacidnom and gipoacidnom gastritis (r < 0.01). In our view, when giperacidozah people consume more NaCl, but the content of the Cl in the saliva, as far as is known, while in giperacidnom gastritis and peptic ulcer disease is not yet known. Cleland J.G.F. o. a. [10] showed that the Serum Na, K and chloride were higher in patients with hypertension of … compared with patients with heart diseases. " In our opinion, and hypertension-(GB) and giperacidozy are caused by excess consumption of salt, so in the serum of hypertension there is a surplus and the sodium and chloride, chloride ion only in hypertensive disease almost no one studied. V. Smith [11] found that in patients with worsening ulcers content vnutrièritrocitarnogo Na-13.6 ± 0.16 mmol/l higher than in healthy-11.8 ± 0.37 mmol/l. Geller, poppy-Giff [12] found that when pigs are feeding NaCl, those "often die from complications arising from stomach ulcers. Sonnenberg a. [13] studied the average intake of salt in food and mortality in different countries when ulcers stomach, revealed directly proportional dependence between the variables.
Omelyanets etc.[14] given the experimental animals 75 mg/l NaCl and 7.5 mg/l KCl simultaneously in distilled water for drinking. After 1 month of declining rates of heart and stomach. At 100 mg/l NaCl and 10 mg/l KCl detected swelling of mucosa o shell of stomach and small intestine, hyperemia, pockets of haemorrhage, plazmorragiâ, in the myocardium-focal degeneration of myocytes. For us, the conclusion is not to buy bottled drinking water containing Cl ¯ more 70-80 mg/l. Kang SA [15] wanted to pathogenesis of pain associated with duodenal ulcer, for which 20 persons possessing such ulcers, with the help of an endoscope irrigated 0, 1N solution the NSl, or saline solution salt ulcerative crater in a double blind experiment. In response to an NSl from ZEF 16 patients had typical peptic ulcer pain. In response to saline solution such pain appeared 4 people (r < 0.005). Of the 16 patients after the disappearance of the pain took away 10 people, irrigation NSl caused sharp pain in all 10 people. Consider that a major role in the pathogenesis of duodenal ulcer pain need to NSl. This work of Kang et al. [15] the ingeniously conceived and performed as the experimentally verified an axiom-no acid, no sores. Observations on work, vdyhavšimi production of hydrofluoric acid-other pairs, sulfuric, nitric, etc, have shown that other acids can also cause giperacidizm, giperatidnyi gastritis and ulcer disease, but in 99% of cases they depend on surplus income of chloride salt with food and water. Here there is a dialectical link between the influence of chlorides and hydrogen ions of mineral acids. As for the "physiological" solution, which has 20% of the patients is typical of ulcer pain-Kang SA [15]; It is not surprising that such a peresolenyj "saline solution" is a typical ulcer pain in patients with peptic ulcer duodeny.
E. Gaidar [16] wrote: "our problems are exacerbated by the powerful alkogolizaciej of the population that has already resulted in contrast to civilized countries, where life expectancy is steadily increasing in Russia since the 70 's, is constantly decreasing, if not war, revolution and alcoholism, the population of Russia has reached the 300 million people". In our opinion, when in Russia vodka salty eats cabbage, pickles, pickled mushrooms, pickled tomatoes, salted or salted and smoked fish, and then in the morning drink with a hangover brines, that more contributes to hypertension and its deadly complications, giperacidizmu and mortality than drinking vodka, because excessive salt intake is the cause of death is no. 1, and alcoholism at 5 or 7 place as cause of death. But to prove it almost need grants for such research. A.l. Grebenev etc. [17] point: from 1978 to 1982, were examined and taken under clinical supervision 130 patients with a combination of peptic ulcer and hypertensive disease. 36 patients with peptic ulcer disease has developed a second time, against the background of hypertensive disease. Analysis of clinical features of both diseases showed that for this group of patients is, above all, severe hypertension: high degree of the hereditary otâgoŝennosti (69.2%) of young (under 40) age of patients at the beginning of the disease (85%) frequent status krizovye; pronounced changes of the fundus; reducing concentrate kidney; low efficiency of hypertensive therapy. the clinical picture and the ulcers were in turn not quite ordinary: later (over 40 years), the development of the disease; showed that the other acids can also cause giperacidizm, giperatidnyi gastritis and ulcer disease, but in 99% of cases they depend on surplus income of chloride salt with food and water. Here there is a dialectical link between the influence of chlorides and hydrogen ions of mineral acids. As for the "physiological" solution, which has 20% of the patients is typical of ulcer pain-Kang SA [15]; It is not surprising that such a peresolenyj "saline solution" is a typical ulcer pain in patients with peptic ulcer duodeny. A.l. Grebenev etc. [17] point: from 1978 to 1982, were examined and taken under clinical supervision 130 patients with a combination of peptic ulcer and hypertensive disease. 36 patients with peptic ulcer disease has developed a second time, against the background of hypertensive disease. Analysis of clinical features of both diseases showed that for this group of patients is, above all, severe hypertension: high degree of the hereditary otâgoŝennosti (69.2%) of young (under 40) age of patients at the beginning of the disease (85%) frequent status krizovye; pronounced changes of the fundus; reducing concentrate kidney; low efficiency of hypertensive therapy. the clinical picture and the ulcers were in turn not quite ordinary: later (over 40 years) development of zabolevaniâ2. Hyperacidity diseases of esophagus, stomach, intestines caused by excessive consumption of chlorides, mainly with table salt. Excess consumption of chlorides is the sole cause of giperacidnogo esophagitis, gastritis, gastric ulcer and duodenal ulcer, ulcerative colitis and enteritis, stomach cancer, which developed the long-term healing of gastric ulcers and kalleznyh and duodeny. This statement or an empirical generalization, this article is published in the us for the first time in the world.
Among the many factors contributing to the formation of stomach ulcers, trudnorubcuûŝihsâ indicate hypertension-is quoted on Baronviski A.y. [18].
Mathisen [19]: when hypernatraemia caused by intravenous injection of 500 ml 2.9% NaCl solution was, prior to the introduction of 142 ± 1 mmol/l Na in plasma (control), and after the introduction-187 ± 3 mmol/l Na in plasma. In our view, under these conditions, it would be interesting to explore, and chloride content in the urine and blood.
By Šeptulinu A. [20] "the combination of ulcers and gastroduodenal ulcers with atherosclerosis, coronary heart disease, hypertonic disease are extremely important, because each of these diseases in isolation is widely distributed among the population. Not all of pathogenetic and clinical aspects of such combinations can be studied; many of the findings require further study and clarification. " Šeptulin A.a. [20], referring to several authors, considers cases of peptic ulcer disease and hypertensive combination is quite rare, but the very same facts that their frequency ranges from 1.1 to 15.2%. In the analysis of (his) own archival material for selectively taken period proved the accompanying hypertension are at 3.4% of patients with peptic ulcer. He argues that some of the patients there is a distinct "synergies" diseases, when acute ulcers are accompanied by worsening of hypertension; in some patients after hypertensive disease there is a clinical cure ulcers, although the General State of the patient (due to the progression of hypertension) can sometimes worsen. According to Šeptulina, A.a. [20], most often (53.8% of cases) is a combination option to ulcers (duodenal localization usually) joins the hypertension. Difficult to assess the mechanism of secondary gastroduodenal ulcers, in the background, pre-existing hypertension, make up, according to his data, 27.7% of the mix. First of all, it should be allot of gastroduodenal ulcers that develop in patients with severe hypertensive crises, violations of cerebral circulation, and manifest profuznymi gastro-intestinal bleeding and ulcers, rupture (A.l. Butchers, 1965, Yamaguchi, 1973) ".
Čeremšanova r. and others. [21], analyzed the medical records of 28 children with peptic ulcer, a family history had instructions on hypertension, gastritis with improved functional ability, ulcer disease, gastric cancer; in all these cases the diagnosis was radiographically.
Kuberger M.b., etc. [22, c. 32], referring to the House of B.g., Melnikova i.Yu., 1986, have interesting data on patients with duodenogastral′nym reflux (esophagitis with): "they are characterized by increased irritability, fatigue, frequent headaches, decreased appetite. In later life, celebrate the lability of the pulse and hell "; labil′nyj pulse and labile AL in children characterized by American data, for the edge of hypertension. In 1988, left work Brunner g. o. a. [23], in which it was shown that peptic ulcers they discovered esophagus; of the 94 patients peptic ulcers of the esophagus, stomach and duodeny have esophageal ulcers were 28. Schindlbeck N.E. a.o. [24] on 10 healthy volunteers conducted 24-hour pH-Metry; želudočnopiŝevodnyj reflux was defined as an episode of lower pH less than 4.0. In the form of a placebo used 3 ml izotoniceski solution of NaCl, which ingalirovali in the lungs and a trend towards increased vnutripiŝevodnogo pressure-Schindlbeck N.E. a.o. [24]. A. Loginoff et al. [25, s. 6], referring to L.p. vorobyeva, Alexander Samsonov, 1985, indicate: "duodeny ulcer patients in the acute phase are expressed by the generalized violations of Microcirculation of … In the period of exacerbation in the conjunctiva of the eyeball were identified changes mikrogemocirkulâcii. The most frequently recorded moderate spasm arteriola (82.5% of the patients). " If you have a spasm of arterioles, then these patients peptic ulcer, it is necessary to explore HELL.
We have a very large gap in the training of cardiologists and gastroenterologists, as long as no data on their common joint training or refresher courses, I have ever seen, and needs in that no one had seen before. In my opinion, all patients with borderline hypertension-PAG (140/90-160/95) and GB (160/95 and above) it is desirable to send the survey to a gastroenterologist, and all patients with giperacidizmom, it is necessary to define the hell anyone HELL above 120/80 or with symptoms of giperacidizma, assigning low-salt diet under control of Na and Cl in one sample of urine. A. Belousov [26] examined 70 healthy people 19-25 years without complaint from gastroskopičeski normal gastric mucosa. The acidity of the gastric contents on bread breakfast most perfectly healthy * is not limited to the generally accepted "normal" values-20-40 for the free HCl and 40-60 for total acidity and gives significant variations in both the downward and upward of these indicators. * People with high acidity wrongfully ended up in a group of healthy, they already had the phenomenon of giperacidizma, these people need to dispanserizovat′ in the first place, before the advent of our paradigm no one on that was not intended. When the monitoring group will be created, or healthy for hypertension and giperacidizmu, from our point of view, it is necessary to other than clinical examination, examine the contents of Na and Cl in the urine; for the healthy maintenance of Na should not exceed 2-3 g/l and Cl ¯-3-3.5 g/l; HELL should not be vysokonormal′nym, i.e. HELL must be less than 120/80. You also need to develop indicators of pH of gastric contents for the healthy. The very notion of a healthy person on gastro-intestinal diseases must be reviewed in the light of our paradigm. Previously, we have developed the concept of the healthy child tooth decay dental B.v. Larionov [4, p. 133]. My student student Gil′mutdinov R.i. [27] referred, on my advice, the work of r. Cooper, etc. (1983), that blood pressure-Hell above 120/80, see vysokonormal′nym. Russia academician G. Belenkov [28] wrote: "for people under the age of 40 years, pressure 120/80 is normal." The term "vysokonormal′noe HELL" was first us [27] introduced Soviet cardiology literature.
3. to prevent hypertension and giperacidizma, it is necessary to reduce the consumption of table salt to sodium ion content in one sample of urine was no more than 2-3 g/l and Cl ¯-3-3.5 g/l to define the Na + and Cl ¯ in liquid environments need to refine and make cheaper Russian glass sodium-and hloridselektivnye electrodes. Such sensors have long been developed in Japan [32].
4. the phenomenon of giperacidizma can cause any mineral acid entering the body of a human or animal, but in 99% of cases they depend on surplus income of chloride salt with food and water.
5. Applied us biogeochemical, odnopričinnyj [33] method to study the etiology and prevention of endemic goiter-Bv Larionov [34.35], caries-Bv Larionov [34, 35, 4] disease, hypertension and hypotension-Bv Larionov [2], we have successfully applied to study the etiology of hyperacid gastritis, duodenitis, colitis, èzofagitov, gastric erosion and duodeny, gastric ulcers and stomach cancer, duodeny and other divisions of the gastroenteric tract (this work on 250 pages of typing soon will be ready for publication). This method can be applied to the study of etiology and prevention of atherosclerosis, strokes, diabetes, appendicitis, cataract, glaucoma, prostate adenoma, Hypo-and giperkal′cinozov-degenerative disc disease, solve Osteoarticular problems successfully correcting, kal′cifikacij vessels, research grants are desirable. This article is part of this neizdannoj book.
PS. before the publication of the monograph [2] Larionov B.v., I sent it in 1983, on the review of the all-Union scientific centre of Cardiology academician Yevgeny Chazov, she lay there for a few months, read the DMN A.a. Nekrasova, and it is controversial. A. Nekrasov was in its scientific and popular papers [36, 37] is very close to my ideas, but a stroke of a pen without reasoned reasons, refused me in publishing. I had to post this job-Bv Larionov [2] in the form of deposited manuscripts. A.a. Nekrasova, together with academician Efim Čazovym, in my opinion, for a few decades, the development of preventive cardiology was detained in the Soviet Union and Russia; under the right circumstances this would save from the death of hundreds of thousands of people because of eating too much salt, hypertension and its deadly complications.
PPS. In the USSR, very good job in ICSTI and INION USSR in refereed journals, allowing low-cost labor and time to any scientists monitor the level of the world scientific literature. After the collapse of the Soviet Union, edition of refereed journals have been almost completely phased out, and now restored on only 3-5%. I for example, more than 10 years on the job in the Kazan Medical Institute had a subscription on an economic agreement entered into 20 refereed journals from 22 on medicine; In addition, wrote out a response journals in human ecology, Biogeochemistry, medgeografii, soil science, analytical chemistry, express information, Dor, lists literature, translations, etc. Now on medicine, instead of 22 editions of the refereed journal is issued one combined the that covers the world medical literature only 5-10%, very weak references, among the speakers a little narrow specialists and they can not or do not know how to choose from the most important articles. Separate releases refereed journals are relatively inexpensive, and now these magazines are very expensive and not always are issued monthly. If the State is interested in innovative science and innovative technologies, it is imperative for 95-99% subsidize production of refereed journals across all fields of science and technology in paper and electronic versions. In addition, it is necessary to teach the use of referativnymi journals high school students, College and university students. Literature 1. Rapoport S.i. Nezavisimaya Gazeta. Circle of life no. 17, PG. 3. December 1998.
2. Larionov B.v. Biogeohimičeskaâ sodium theory of etiology, prevention, and the geographical spread of disease hypertension and hypotension. Money deposited the manuscript. D-8582. C. 1-89. Kazan. 1984.
3. Efremov Z.k., Krylova R.i. Journal of the Academy of medical sciences of the USSR, 1973, no. 12.
4. how to salvage B.v. Larionov teeth? (Lack of fluoride is the only cause of tooth decay. the new paradigm biogeohimičeskaâ. Ftorprofilaktika, etiology, prognosis and geographic distribution of primary developed and complicated caries). Kazan, Samizdat. 2006.170 c.
5. Glazunov I.s. risk of cardiovascular and other noncommunicable diseases and its evaluation of mass population surveys. Survey information. M. 1989, ISS. 4.
6. Rannak E.d. Nature, 1966, 9, pp. 10-16.
7. Šeptulin a.a., Kurteanu B.n. Modern pathogenetic concepts of stomach ulcers. M., 1983, 1-15. Money deposited the manuscript VNIIMI the MINISTRY OF HEALTH of the USSR No. 83-7181.
8. V.k. Fadeev in hygiene and sanitation, 1971, 6, 11-15.
9. Radbil′ o.s., Weinstein, the adrenal Cortex and peptic ulcer disease. Kazan. Ed. KSU. 1967.
10. Cleland J.G.F. o. a., 1987, p. 233.
11. Ivanov, V.m. functional-morphological and clinical examination of medical application of nerobola and gipotiazida with ulcers. Synopsis of the DICs. k. m. n. l. VMOLA. 1987, 1-9.
12. r. j. Geller, poppy-Giff D.s. arterial hypertension. M. Medicine, 1980, 101-109.
13. Sonnenberg a.//Gut, 1986, 27, 10, 1138-1142.
14. N.i. Omelyanets etc. Hygiene of localities. Kiev. Health. 1984, ISS. 23, 72-77.
15. J.Y. Kang, Yap i., Guan R., Tay h.h.//Gut, 1986, 27, 8, 942-945.
16. Gaydar is right (newspaper). 28.02-6.03. 2003.
17. Grebenev a.l., A.a. Šeptulin A.a. etc. Clinical medicine, 1991, 11, 59-64.
18. Baranovsky A. Forecast trends and possible preventive treatment of ulcers of the stomach. NGO Soûzmedinform. M. 1991, pp. 1-73.
19. Mathisen, o., Raeder M.//Scand j. Gastroenterol. 1983, 18, 8, 825-832.
20. Šeptulin A.a. Cardiovascular Disease and peptic ulcers. Money deposited the manuscript VNIIMI the MINISTRY OF HEALTH of the USSR № 13642. M. 1985, 101-111.
21. Čeremšanova, r., Lobovikova t., Doronikina n. pathology of digestive system. Materials VI all-Union students ' scientific conference. Donetsk-Kharkiv. 1975, 342-343.
22. Kuberger m.b., Kapustin a.v., Khavkin A.i. biliary and Gastroesophageal refluxes. Medical abstract journal "Pediatrics", 1984, V, 4, literature review, 28-33, summary No. 778.
23. Brunner g. Creutzfeldt, w., Hrake u., Lamberts r.//Digestion, 1988, 39, 2, 80-90.
24. Schindlbeck N.E., Heinrch ch. Huber, R.M., Müller-Lissner S.A.//JAMA, 1988, 260, 21, 3156-3158.
25. A. Loginoff, v. Alekseev, o.s. Radbil′. Introduction of new methods of diagnosis and treatment of ulcers stomach and duodenal ulcer in the practice of public health. Express information VNIIMI the MINISTRY OF HEALTH of the USSR. Iss. 9. m. 1986, pp. 1-36.
26. Mr. A.s. medical business, 1958, 9, 913-918.
27. Gil′mutdinov r. (student course 6 Kazan Medical Institute and Scientific Director of Bv Larionov). On the role of heredity in the etiology of hypertension. Problems of General and medical genetics. Irkutsk. 1986, 5-5.
28. Belenkov Yn how to preserve quality of life and life in General. Article By Irina Maltsev. The independent newspaper. 19.02.1999.
29. Zats a.a., Scribe A.z. biological role of chemical elements and the use of the most important
inorganic compounds in medicine. M. 1986, 1-43.
30. Byzov T.n. et al. Money deposited manuscript no. 85-9808. VNIIMI the MINISTRY OF HEALTH of the USSR, Yaroslavl, 1985, 1-6.
31. Vantyghem M.C. Lefebvre, j.//Sem Hop. 1987, 63, 32, 2631-2641.
32. himiya I zhizn, 1975, 3, reprint of "Kyodo Service" from 5.10.1974.
33. Larionov B.v. Monism and odnopričinnost′ in philosophy, geography and medicine. Geography and region. Perm, Perm State University, 2002, pp. 213-217.
34. Larionov B.v. to predicting the incidence of èndemiâmi in the construction of the biogeochemical future Boguchanskaya hpp. -In: hygiene, pathology and Oncology in Siberia. Angarsk, 1967, pp. 66-70.
35. Larionov B.v. on forecasting the incidence and etiology of endemic goitre and tooth decay. -Biogeography and study of local lore. Perm, 1976, ISS. 4, pp. 85-105.
36. A. Nekrasova health, 1980, no. 8, pp. 10-11.
37. A. Nekrasova, Gazaryan Fatula, g.a., M.i. and others. Arterial hypertension. M. Medicine, 1980, p. 272-281.

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Work published: scientific papers and materials of the Fifth International Symposium 26-May 28, 2008 Vol. 3. Kazan. 2008.
THE EFFECT OF EXCESS CHLORIDES ON THE EMERGENCE OF STATE-ÈZOFAGITOV HYPERACID, GASTRITIS, DUODENITIS, ENTERITIS, ULCERATIVE COLITIS, ULCERS OF THE ESOPHAGUS, STOMACH AND DUODENAL ULCERS, ESOPHAGEAL CANCER, STOMACH CANCER AND BOWEL CANCER (NEW BIOGEOHIMIČESKAÂ ODNOPRIČINNAÂ PARADIGM)
B.v. Larionov
The Committee for the study of the phenomena of nature and human ecology RT (Kazan)
“Enigma of the ulcer still not solved”-Professor S. Rapoport [1].
When I wrote a monograph on salt and hypertension-Bv Larionov [2], read the work of Ephraim, Z.k., R.i. Krylova “features of experimental hypertension and the pathological feature changes in monkeys with chronic stress table salt” [3]. After that, I began to search for publications by the excess consumption of salt with a group of diseases, which I called giperacidizmom. Then I wrote a book called “how to save teeth?”, released as a self-published-Bv Larionov [4], but continued to collect materials on giperacidozam. Z.k. Efremova, R.i. Krylova [3], studied the effect of the salt diet on the development of hypertension in monkeys, but the first in the world to describe and change them in the gastrointestinal tract. In the experiment used 31 monkey species of hamadryas Baboon Baboon, ranging in age from 2 months to 7 years old (by the beginning of the experiment), including 4 calves from their mothers on the salt diet. The monkeys received NaCl in the amount of 2-3% of the total weight of food (26-30 g for adults and 8-16, 2011 for teens) every day. In the course of the experiment killed 13 monkeys, found defects in the stomach mucous membrane type erosions or ulcers in the intestine is a constant phenomenon of inflammation: from small hemorrhages in the Mucosa to paintings express katarral′nogo inflammation in a particular department. When bacteriological examination of pathogenic flora is not to …The immediate cause of death for 7 monkeys, have been the phenomenon of inflammation in the mucosa of the stomach, liver, heart and adrenal gland. I.s. Glazunov [5] refers to a very interesting data: as for stomach cancer, the hypothesis is that excessive salt intake increases the acidity of gastric juice and gastric lesions rise accordingly-(102-104). ” Rannak E.d. [6] wrote: there is an indication that the salted or bezsol′naâ diet has beneficial effects not only the swelling, inflammation of the kidneys and high blood pressure, but when the chest the Toad (strokes), arteriosclerosis, gastric ulcers and duodeny (duodenum-duodenum), glaucoma, etc. Šeptulin A. A., Kurteanu B. N. [7] presented the modern theory of pathogenesis of peptic ulcer disease: acid-peptic aggression back diffusion of hydrogen ions, duodenogastral′nogo reflux, gastritičeskih changes vascular disorders. This article was for us further proof that only one is our theory is a paradigm of the acid aggression due to excess HCl education, due to excess intake of NaCl. V.k. Fadeeva [8] in experiments on rats has received reports that in the blood of rats “is increasing the number of Na and Cl, since concentrations of Cl (in water) 1 g/l and above. S. Radbil′, s. Weinstein [9, p. 91] have studied the contents of Na in mixed saliva at 195 patients with various diseases of the stomach and duodeny of 89 patients with peptic ulcer. It turned out that the concentration of Na in giperacidnom gastritis and ulcers was significantly higher than normacidnom and gipoacidnom gastritis (r < 0.01). In our view, when giperacidozah people consume more NaCl, but the content of the Cl in the saliva, as far as is known, while in giperacidnom gastritis and peptic ulcer disease is not yet known. Cleland J.G.F. o. a. [10] showed that the Serum Na, K and chloride were higher in patients with hypertension of … compared with patients with heart diseases. " In our opinion, and hypertension-(GB) and giperacidozy are caused by excess consumption of salt, so in the serum of hypertension there is a surplus and the sodium and chloride, chloride ion only in hypertensive disease almost no one studied. V. Smith [11] found that in patients with worsening ulcers content vnutrièritrocitarnogo Na-13.6 ± 0.16 mmol/l higher than in healthy-11.8 ± 0.37 mmol/l. Geller, poppy-Giff [12] found that when pigs are feeding NaCl, those "often die from complications arising from stomach ulcers. Sonnenberg a. [13] studied the average intake of salt in food and mortality in different countries when ulcers stomach, revealed directly proportional dependence between the variables.
Omelyanets etc.[14] given the experimental animals 75 mg/l NaCl and 7.5 mg/l KCl simultaneously in distilled water for drinking. After 1 month of declining rates of heart and stomach. At 100 mg/l NaCl and 10 mg/l KCl detected swelling of mucosa o shell of stomach and small intestine, hyperemia, pockets of haemorrhage, plazmorragiâ, in the myocardium-focal degeneration of myocytes. For us, the conclusion is not to buy bottled drinking water containing Cl ¯ more 70-80 mg/l. Kang SA [15] wanted to pathogenesis of pain associated with duodenal ulcer, for which 20 persons possessing such ulcers, with the help of an endoscope irrigated 0, 1N solution the NSl, or saline solution salt ulcerative crater in a double blind experiment. In response to an NSl from ZEF 16 patients had typical peptic ulcer pain. In response to saline solution such pain appeared 4 people (r < 0.005). Of the 16 patients after the disappearance of the pain took away 10 people, irrigation NSl caused sharp pain in all 10 people. Consider that a major role in the pathogenesis of duodenal ulcer pain need to NSl. This work of Kang et al. [15] the ingeniously conceived and performed as the experimentally verified an axiom-no acid, no sores. Observations on work, vdyhavšimi production of hydrofluoric acid-other pairs, sulfuric, nitric, etc, have shown that other acids can also cause giperacidizm, giperatidnyi gastritis and ulcer disease, but in 99% of cases they depend on surplus income of chloride salt with food and water. Here there is a dialectical link between the influence of chlorides and hydrogen ions of mineral acids. As for the "physiological" solution, which has 20% of the patients is typical of ulcer pain-Kang SA [15]; It is not surprising that such a peresolenyj "saline solution" is a typical ulcer pain in patients with peptic ulcer duodeny.
E. Gaidar [16] wrote: "our problems are exacerbated by the powerful alkogolizaciej of the population that has already resulted in contrast to civilized countries, where life expectancy is steadily increasing in Russia since the 70 's, is constantly decreasing, if not war, revolution and alcoholism, the population of Russia has reached the 300 million people". In our opinion, when in Russia vodka salty eats cabbage, pickles, pickled mushrooms, pickled tomatoes, salted or salted and smoked fish, and then in the morning drink with a hangover brines, that more contributes to hypertension and its deadly complications, giperacidizmu and mortality than drinking vodka, because excessive salt intake is the cause of death is no. 1, and alcoholism at 5 or 7 place as cause of death. But to prove it almost need grants for such research. A.l. Grebenev etc. [17] point: from 1978 to 1982, were examined and taken under clinical supervision 130 patients with a combination of peptic ulcer and hypertensive disease. 36 patients with peptic ulcer disease has developed a second time, against the background of hypertensive disease. Analysis of clinical features of both diseases showed that for this group of patients is, above all, severe hypertension: high degree of the hereditary otâgoŝennosti (69.2%) of young (under 40) age of patients at the beginning of the disease (85%) frequent status krizovye; pronounced changes of the fundus; reducing concentrate kidney; low efficiency of hypertensive therapy. the clinical picture and the ulcers were in turn not quite ordinary: later (over 40 years), the development of the disease; showed that the other acids can also cause giperacidizm, giperatidnyi gastritis and ulcer disease, but in 99% of cases they depend on surplus income of chloride salt with food and water. Here there is a dialectical link between the influence of chlorides and hydrogen ions of mineral acids. As for the "physiological" solution, which has 20% of the patients is typical of ulcer pain-Kang SA [15]; It is not surprising that such a peresolenyj "saline solution" is a typical ulcer pain in patients with peptic ulcer duodeny. A.l. Grebenev etc. [17] point: from 1978 to 1982, were examined and taken under clinical supervision 130 patients with a combination of peptic ulcer and hypertensive disease. 36 patients with peptic ulcer disease has developed a second time, against the background of hypertensive disease. Analysis of clinical features of both diseases showed that for this group of patients is, above all, severe hypertension: high degree of the hereditary otâgoŝennosti (69.2%) of young (under 40) age of patients at the beginning of the disease (85%) frequent status krizovye; pronounced changes of the fundus; reducing concentrate kidney; low efficiency of hypertensive therapy. the clinical picture and the ulcers were in turn not quite ordinary: later (over 40 years) development of zabolevaniâ2. Hyperacidity diseases of esophagus, stomach, intestines caused by excessive consumption of chlorides, mainly with table salt. Excess consumption of chlorides is the sole cause of giperacidnogo esophagitis, gastritis, gastric ulcer and duodenal ulcer, ulcerative colitis and enteritis, stomach cancer, which developed the long-term healing of gastric ulcers and kalleznyh and duodeny. This statement or an empirical generalization, this article is published in the us for the first time in the world.
Among the many factors contributing to the formation of stomach ulcers, trudnorubcuûŝihsâ indicate hypertension-is quoted on Baronviski A.y. [18].
Mathisen [19]: when hypernatraemia caused by intravenous injection of 500 ml 2.9% NaCl solution was, prior to the introduction of 142 ± 1 mmol/l Na in plasma (control), and after the introduction-187 ± 3 mmol/l Na in plasma. In our view, under these conditions, it would be interesting to explore, and chloride content in the urine and blood.
By Šeptulinu A. [20] "the combination of ulcers and gastroduodenal ulcers with atherosclerosis, coronary heart disease, hypertonic disease are extremely important, because each of these diseases in isolation is widely distributed among the population. Not all of pathogenetic and clinical aspects of such combinations can be studied; many of the findings require further study and clarification. " Šeptulin A.a. [20], referring to several authors, considers cases of peptic ulcer disease and hypertensive combination is quite rare, but the very same facts that their frequency ranges from 1.1 to 15.2%. In the analysis of (his) own archival material for selectively taken period proved the accompanying hypertension are at 3.4% of patients with peptic ulcer. He argues that some of the patients there is a distinct "synergies" diseases, when acute ulcers are accompanied by worsening of hypertension; in some patients after hypertensive disease there is a clinical cure ulcers, although the General State of the patient (due to the progression of hypertension) can sometimes worsen. According to Šeptulina, A.a. [20], most often (53.8% of cases) is a combination option to ulcers (duodenal localization usually) joins the hypertension. Difficult to assess the mechanism of secondary gastroduodenal ulcers, in the background, pre-existing hypertension, make up, according to his data, 27.7% of the mix. First of all, it should be allot of gastroduodenal ulcers that develop in patients with severe hypertensive crises, violations of cerebral circulation, and manifest profuznymi gastro-intestinal bleeding and ulcers, rupture (A.l. Butchers, 1965, Yamaguchi, 1973) ".
Čeremšanova r. and others. [21], analyzed the medical records of 28 children with peptic ulcer, a family history had instructions on hypertension, gastritis with improved functional ability, ulcer disease, gastric cancer; in all these cases the diagnosis was radiographically.
Kuberger M.b., etc. [22, c. 32], referring to the House of B.g., Melnikova i.Yu., 1986, have interesting data on patients with duodenogastral′nym reflux (esophagitis with): "they are characterized by increased irritability, fatigue, frequent headaches, decreased appetite. In later life, celebrate the lability of the pulse and hell "; labil′nyj pulse and labile AL in children characterized by American data, for the edge of hypertension. In 1988, left work Brunner g. o. a. [23], in which it was shown that peptic ulcers they discovered esophagus; of the 94 patients peptic ulcers of the esophagus, stomach and duodeny have esophageal ulcers were 28. Schindlbeck N.E. a.o. [24] on 10 healthy volunteers conducted 24-hour pH-Metry; želudočnopiŝevodnyj reflux was defined as an episode of lower pH less than 4.0. In the form of a placebo used 3 ml izotoniceski solution of NaCl, which ingalirovali in the lungs and a trend towards increased vnutripiŝevodnogo pressure-Schindlbeck N.E. a.o. [24]. A. Loginoff et al. [25, s. 6], referring to L.p. vorobyeva, Alexander Samsonov, 1985, indicate: "duodeny ulcer patients in the acute phase are expressed by the generalized violations of Microcirculation of … In the period of exacerbation in the conjunctiva of the eyeball were identified changes mikrogemocirkulâcii. The most frequently recorded moderate spasm arteriola (82.5% of the patients). " If you have a spasm of arterioles, then these patients peptic ulcer, it is necessary to explore HELL.
We have a very large gap in the training of cardiologists and gastroenterologists, as long as no data on their common joint training or refresher courses, I have ever seen, and needs in that no one had seen before. In my opinion, all patients with borderline hypertension-PAG (140/90-160/95) and GB (160/95 and above) it is desirable to send the survey to a gastroenterologist, and all patients with giperacidizmom, it is necessary to define the hell anyone HELL above 120/80 or with symptoms of giperacidizma, assigning low-salt diet under control of Na and Cl in one sample of urine. A. Belousov [26] examined 70 healthy people 19-25 years without complaint from gastroskopičeski normal gastric mucosa. The acidity of the gastric contents on bread breakfast most perfectly healthy * is not limited to the generally accepted "normal" values-20-40 for the free HCl and 40-60 for total acidity and gives significant variations in both the downward and upward of these indicators. * People with high acidity wrongfully ended up in a group of healthy, they already had the phenomenon of giperacidizma, these people need to dispanserizovat′ in the first place, before the advent of our paradigm no one on that was not intended. When the monitoring group will be created, or healthy for hypertension and giperacidizmu, from our point of view, it is necessary to other than clinical examination, examine the contents of Na and Cl in the urine; for the healthy maintenance of Na should not exceed 2-3 g/l and Cl ¯-3-3.5 g/l; HELL should not be vysokonormal′nym, i.e. HELL must be less than 120/80. You also need to develop indicators of pH of gastric contents for the healthy. The very notion of a healthy person on gastro-intestinal diseases must be reviewed in the light of our paradigm. Previously, we have developed the concept of the healthy child tooth decay dental B.v. Larionov [4, p. 133]. My student student Gil′mutdinov R.i. [27] referred, on my advice, the work of r. Cooper, etc. (1983), that blood pressure-Hell above 120/80, see vysokonormal′nym. Russia academician G. Belenkov [28] wrote: "for people under the age of 40 years, pressure 120/80 is normal." The term "vysokonormal′noe HELL" was first us [27] introduced Soviet cardiology literature.
3. to prevent hypertension and giperacidizma, it is necessary to reduce the consumption of table salt to sodium ion content in one sample of urine was no more than 2-3 g/l and Cl ¯-3-3.5 g/l to define the Na + and Cl ¯ in liquid environments need to refine and make cheaper Russian glass sodium-and hloridselektivnye electrodes. Such sensors have long been developed in Japan [32].
4. the phenomenon of giperacidizma can cause any mineral acid entering the body of a human or animal, but in 99% of cases they depend on surplus income of chloride salt with food and water.
5. Applied us biogeochemical, odnopričinnyj [33] method to study the etiology and prevention of endemic goiter-Bv Larionov [34.35], caries-Bv Larionov [34, 35, 4] disease, hypertension and hypotension-Bv Larionov [2], we have successfully applied to study the etiology of hyperacid gastritis, duodenitis, colitis, èzofagitov, gastric erosion and duodeny, gastric ulcers and stomach cancer, duodeny and other divisions of the gastroenteric tract (this work on 250 pages of typing soon will be ready for publication). This method can be applied to the study of etiology and prevention of atherosclerosis, strokes, diabetes, appendicitis, cataract, glaucoma, prostate adenoma, Hypo-and giperkal′cinozov-degenerative disc disease, solve Osteoarticular problems successfully correcting, kal′cifikacij vessels, research grants are desirable. This article is part of this neizdannoj book.
PS. before the publication of the monograph [2] Larionov B.v., I sent it in 1983, on the review of the all-Union scientific centre of Cardiology academician Yevgeny Chazov, she lay there for a few months, read the DMN A.a. Nekrasova, and it is controversial. A. Nekrasov was in its scientific and popular papers [36, 37] is very close to my ideas, but a stroke of a pen without reasoned reasons, refused me in publishing. I had to post this job-Bv Larionov [2] in the form of deposited manuscripts. A.a. Nekrasova, together with academician Efim Čazovym, in my opinion, for a few decades, the development of preventive cardiology was detained in the Soviet Union and Russia; under the right circumstances this would save from the death of hundreds of thousands of people because of eating too much salt, hypertension and its deadly complications.
PPS. In the USSR, very good job in ICSTI and INION USSR in refereed journals, allowing low-cost labor and time to any scientists monitor the level of the world scientific literature. After the collapse of the Soviet Union, edition of refereed journals have been almost completely phased out, and now restored on only 3-5%. I for example, more than 10 years on the job in the Kazan Medical Institute had a subscription on an economic agreement entered into 20 refereed journals from 22 on medicine; In addition, wrote out a response journals in human ecology, Biogeochemistry, medgeografii, soil science, analytical chemistry, express information, Dor, lists literature, translations, etc. Now on medicine, instead of 22 editions of the refereed journal is issued one combined the that covers the world medical literature only 5-10%, very weak references, among the speakers a little narrow specialists and they can not or do not know how to choose from the most important articles. Separate releases refereed journals are relatively inexpensive, and now these magazines are very expensive and not always are issued monthly. If the State is interested in innovative science and innovative technologies, it is imperative for 95-99% subsidize production of refereed journals across all fields of science and technology in paper and electronic versions. In addition, it is necessary to teach the use of referativnymi journals high school students, College and university students. Literature 1. Rapoport S.i. Nezavisimaya Gazeta. Circle of life no. 17, PG. 3. December 1998.
2. Larionov B.v. Biogeohimičeskaâ sodium theory of etiology, prevention, and the geographical spread of disease hypertension and hypotension. Money deposited the manuscript. D-8582. C. 1-89. Kazan. 1984.
3. Efremov Z.k., Krylova R.i. Journal of the Academy of medical sciences of the USSR, 1973, no. 12.
4. how to salvage B.v. Larionov teeth? (Lack of fluoride is the only cause of tooth decay. the new paradigm biogeohimičeskaâ. Ftorprofilaktika, etiology, prognosis and geographic distribution of primary developed and complicated caries). Kazan, Samizdat. 2006.170 c.
5. Glazunov I.s. risk of cardiovascular and other noncommunicable diseases and its evaluation of mass population surveys. Survey information. M. 1989, ISS. 4.
6. Rannak E.d. Nature, 1966, 9, pp. 10-16.
7. Šeptulin a.a., Kurteanu B.n. Modern pathogenetic concepts of stomach ulcers. M., 1983, 1-15. Money deposited the manuscript VNIIMI the MINISTRY OF HEALTH of the USSR No. 83-7181.
8. V.k. Fadeev in hygiene and sanitation, 1971, 6, 11-15.
9. Radbil′ o.s., Weinstein, the adrenal Cortex and peptic ulcer disease. Kazan. Ed. KSU. 1967.
10. Cleland J.G.F. o. a., 1987, p. 233.
11. Ivanov, V.m. functional-morphological and clinical examination of medical application of nerobola and gipotiazida with ulcers. Synopsis of the DICs. k. m. n. l. VMOLA. 1987, 1-9.
12. r. j. Geller, poppy-Giff D.s. arterial hypertension. M. Medicine, 1980, 101-109.
13. Sonnenberg a.//Gut, 1986, 27, 10, 1138-1142.
14. N.i. Omelyanets etc. Hygiene of localities. Kiev. Health. 1984, ISS. 23, 72-77.
15. J.Y. Kang, Yap i., Guan R., Tay h.h.//Gut, 1986, 27, 8, 942-945.
16. Gaydar is right (newspaper). 28.02-6.03. 2003.
17. Grebenev a.l., A.a. Šeptulin A.a. etc. Clinical medicine, 1991, 11, 59-64.
18. Baranovsky A. Forecast trends and possible preventive treatment of ulcers of the stomach. NGO Soûzmedinform. M. 1991, pp. 1-73.
19. Mathisen, o., Raeder M.//Scand j. Gastroenterol. 1983, 18, 8, 825-832.
20. Šeptulin A.a. Cardiovascular Disease and peptic ulcers. Money deposited the manuscript VNIIMI the MINISTRY OF HEALTH of the USSR № 13642. M. 1985, 101-111.
21. Čeremšanova, r., Lobovikova t., Doronikina n. pathology of digestive system. Materials VI all-Union students ' scientific conference. Donetsk-Kharkiv. 1975, 342-343.
22. Kuberger m.b., Kapustin a.v., Khavkin A.i. biliary and Gastroesophageal refluxes. Medical abstract journal "Pediatrics", 1984, V, 4, literature review, 28-33, summary No. 778.
23. Brunner g. Creutzfeldt, w., Hrake u., Lamberts r.//Digestion, 1988, 39, 2, 80-90.
24. Schindlbeck N.E., Heinrch ch. Huber, R.M., Müller-Lissner S.A.//JAMA, 1988, 260, 21, 3156-3158.
25. A. Loginoff, v. Alekseev, o.s. Radbil′. Introduction of new methods of diagnosis and treatment of ulcers stomach and duodenal ulcer in the practice of public health. Express information VNIIMI the MINISTRY OF HEALTH of the USSR. Iss. 9. m. 1986, pp. 1-36.
26. Mr. A.s. medical business, 1958, 9, 913-918.
27. Gil′mutdinov r. (student course 6 Kazan Medical Institute and Scientific Director of Bv Larionov). On the role of heredity in the etiology of hypertension. Problems of General and medical genetics. Irkutsk. 1986, 5-5.
28. Belenkov Yn how to preserve quality of life and life in General. Article By Irina Maltsev. The independent newspaper. 19.02.1999.
29. Zats a.a., Scribe A.z. biological role of chemical elements and the use of the most important
inorganic compounds in medicine. M. 1986, 1-43.
30. Byzov T.n. et al. Money deposited manuscript no. 85-9808. VNIIMI the MINISTRY OF HEALTH of the USSR, Yaroslavl, 1985, 1-6.
31. Vantyghem M.C. Lefebvre, j.//Sem Hop. 1987, 63, 32, 2631-2641.
32. himiya I zhizn, 1975, 3, reprint of "Kyodo Service" from 5.10.1974.
33. Larionov B.v. Monism and odnopričinnost′ in philosophy, geography and medicine. Geography and region. Perm, Perm State University, 2002, pp. 213-217.
34. Larionov B.v. to predicting the incidence of èndemiâmi in the construction of the biogeochemical future Boguchanskaya hpp. -In: hygiene, pathology and Oncology in Siberia. Angarsk, 1967, pp. 66-70.
35. Larionov B.v. on forecasting the incidence and etiology of endemic goitre and tooth decay. -Biogeography and study of local lore. Perm, 1976, ISS. 4, pp. 85-105.
36. A. Nekrasova health, 1980, no. 8, pp. 10-11.
37. A. Nekrasova, Gazaryan Fatula, g.a., M.i. and others. Arterial hypertension. M. Medicine, 1980, p. 272-281.

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